The Center clinicians maintain close contact with their patients. For successful treatment of bipolar disorder it is important to anticipate the upcoming episode and change the treatment accordingly. As the medical saying goes, the psychiatrists need to “stay ahead of mania,” rather than “chase mania.” Both manic and depressive episodes can start slowly and the very first symptoms are not easy to recognize. These symptoms are different from person to person and could be as “innocent” as listening to different music, cancelling weekly lunch with a friend, or even a change in the voice or lipstick color. The Center clinicians make it their priority to identify the early symptoms for each individual patient and to change the treatment proactively.